Deuschl G, Wilms H, Krack P, Würker M, Heiss W D
Department of Neurology, Christian Albrechts-Universität, Kiel, Germany.
Ann Neurol. 1999 Jul;46(1):126-8. doi: 10.1002/1531-8249(199907)46:1<126::aid-ana20>3.0.co;2-3.
We describe a patient who developed Parkinson's disease (PD) 17 years after resection of his right cerebellum because of a Lindau tumor. He showed a classic 4.3-Hz resting tremor on the left side but a 3.1-Hz resting, postural, and intention tremor on the right side compatible with midbrain tremor (Holmes' tremor). We conclude that the generator of the tremor in PD cannot be located within the olivocerebellar loop. The cerebellum, however, seems to modulate the tremor frequency of parkinsonian rest tremor and may prevent the rest tremor from transforming into a postural and goal-directed tremor.
我们描述了一名因林道氏肿瘤切除右侧小脑17年后患上帕金森病（PD）的患者。他左侧表现为典型的4.3赫兹静止性震颤，而右侧则出现3.1赫兹的静止性、姿势性和意向性震颤，与中脑震颤（霍姆斯震颤）相符。我们得出结论，帕金森病震颤的起源部位不在橄榄小脑环路内。然而，小脑似乎能调节帕金森病静止性震颤的震颤频率，并可能防止静止性震颤转变为姿势性和目标导向性震颤。
