Isaias Ioannis U, Marzegan Alberto, Pezzoli Gianni, Marotta Giorgio, Canesi Margherita, Biella Gabriele E M, Volkmann Jens, Cavallari Paolo
Dipartimento di Fisiologia Umana, Laboratorio Analisi del Movimento L.A.M.B., Università degli Studi di Milano Milano, Italy.
Front Hum Neurosci. 2012 Jan 3;5:179. doi: 10.3389/fnhum.2011.00179. eCollection 2011.
We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease (PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression. Clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (DAT) binding values investigated by single photon computed tomography imaging (SPECT) with [(123)I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane (FP-CIT). The intensity of tremor (i.e., the power of Electromyography [EMG] signals), but not its frequency, significantly increased during the task. In six subjects, tremor appeared selectively during the task. In a second part of the study, we retrospectively reviewed SPECT with FP-CIT data and confirmed the lack of correlation between dopaminergic loss and tremor by comparing DAT binding values of 82 PD subjects with bilateral tremor (n = 27), unilateral tremor (n = 22), and no tremor (n = 33). This study suggests a role of the LC in Parkinson tremor.
我们分析了静止性震颤，这是帕金森病（PD）病因学上最难以捉摸的特征之一，对12例连续的PD患者在一项激活蓝斑（LC）的特定任务中进行分析，以研究去甲肾上腺素（NA）在震颤产生和抑制中的假定作用。通过单光子计算机断层扫描成像（SPECT）使用[（123）I] N-ω-氟丙基-2β-甲氧基羰基-3β-（4-碘苯基）托烷（FP-CIT）研究多巴胺再摄取转运体（DAT）结合值降低，在所有受试者中证实了临床诊断。在任务期间，震颤强度（即肌电图[EMG]信号的功率）显著增加，但其频率没有增加。在6名受试者中，震颤在任务期间选择性出现。在研究的第二部分，我们回顾性地分析了FP-CIT SPECT数据，并通过比较82例有双侧震颤（n = 27）、单侧震颤（n = 22）和无震颤（n = 33）的PD受试者的DAT结合值，证实多巴胺能缺失与震颤之间缺乏相关性。这项研究表明LC在帕金森震颤中起作用。
