氯氮平与近期起病的精神分裂症及其他精神障碍患者的强迫观念
Clozapine and obsessions in patients with recent-onset schizophrenia and other psychotic disorders.
作者信息
de Haan L, Linszen D H, Gorsira R
机构信息
Department of Psychiatry, Adolescentclinic, Academic Medical Center, University of Amsterdam, The Netherlands.
出版信息
J Clin Psychiatry. 1999 Jun;60(6):364-5. doi: 10.4088/jcp.v60n0603.
BACKGROUND
The increase or emergence of obsessions was compared in young patients with recent-onset schizophrenia or other psychotic disorders taking clozapine and other antipsychotic drugs.
METHOD
We conducted a retrospective cohort study. Subjects were 121 consecutively admitted patients diagnosed with DSM-III-R schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychotic disorder not otherwise specified. Obsessions were diagnosed according to DSM-IV criteria.
RESULTS
More clozapine-treated subjects (20.6%) than subjects treated with other antipsychotic drugs (1.3%) experienced an emergence or increase of obsessions (p<.01).
CONCLUSION
Use of clozapine is associated with the emergence or increase of obsessions in early-phase schizophrenia.
背景
比较了近期发病的精神分裂症或其他精神病性障碍的年轻患者服用氯氮平和其他抗精神病药物后强迫观念的增加或出现情况。
方法
我们进行了一项回顾性队列研究。研究对象为121例连续入院的患者，他们被诊断为DSM-III-R精神分裂症、分裂情感性障碍、精神分裂症样障碍或未另行规定的精神病性障碍。强迫观念根据DSM-IV标准进行诊断。
结果
与使用其他抗精神病药物治疗的患者（1.3%）相比，更多接受氯氮平治疗的患者（20.6%）出现了强迫观念的出现或增加（p<0.01）。
结论
在早期精神分裂症中，使用氯氮平与强迫观念的出现或增加有关。
Zotero 插件