Ghaemi S N, Zarate C A, Popli A P, Pillay S S, Cole J O
Psychopharmacology Program, McLean Hospital, Massachusetts General Hospital, Belmont 02114, USA.
Compr Psychiatry. 1995 Jul-Aug;36(4):267-70. doi: 10.1016/s0010-440x(95)90071-3.
The emergence of obsessive-compulsive symptoms during clozapine treatment has been reported in recent case studies, yet the incidence and significance of this finding is still unclear pending reliable data from a larger sample of patients. Hospital records of 142 randomly selected inpatients started on clozapine treatment at McLean Hospital before July 1, 1992, were reviewed retrospectively. Based on a limited retrospective chart review, there were no definitive cases of patients who developed obsessive-compulsive disorder (OCD) or whose OCD worsened as a result of clozapine treatment. Although some fluctuation of OCD symptoms may have occurred in two cases, it is unclear whether those symptoms were related to treatment with clozapine (or other psychotropic drugs) or to undulations in the natural history of OCD. No definitive relationship between OCD symptoms and clozapine treatment could be established in this limited study. Further clarification of this matter awaits outcome research using prospective methodologies.
近期的病例研究报告了氯氮平治疗期间出现强迫症状的情况，但在获得来自更多患者样本的可靠数据之前，这一发现的发生率及意义仍不明确。对1992年7月1日前在麦克莱恩医院开始接受氯氮平治疗的142名随机选择的住院患者的医院记录进行了回顾性审查。基于有限的回顾性病历审查，没有明确的病例显示患者出现了强迫症（OCD）或其强迫症因氯氮平治疗而恶化。尽管两例患者的强迫症状可能出现了一些波动，但尚不清楚这些症状是否与氯氮平（或其他精神药物）治疗有关，还是与强迫症自然病程中的波动有关。在这项有限的研究中，无法确定强迫症状与氯氮平治疗之间的明确关系。此事的进一步澄清有待采用前瞻性方法进行的结果研究。
