Imanishi Y, Mitogawa Y, Takizawa M, Konno S, Samuta H, Ohsawa A, Kawaguchi A, Fujikawa M, Sakaida H, Shinagawa T, Yamashita H
Department of Radiology, St. Marianna University Tohyoko Hospital, Kanagawa-ken, Japan.
Clin Nucl Med. 1999 Jul;24(7):511-3. doi: 10.1097/00003072-199907000-00008.
Relapsing polychondritis is a generalized recurring disease of cartilage that involves joints, trachea, bronchi, laryngeal cartilages, costal cartilages, and cartilages of the ear and nose. It is associated with autoimmune diseases, including Hashimoto disease in some cases.
The authors evaluated a 29-year-old man with relapsing polychondritis who had symptoms and signs of a common cold for 2 months and anterior chest pain near the sternum for 1 month.
After the diagnosis, the authors found that the patient had a history of thyroid therapy for hyperthyroidism 15 years before. Tc-99m MDP bone scintigraphy performed to evaluate anterior chest pain showed diffusely increased accumulation of radioactivity in all costocartilages and sternoclavicular joints. Based on that information, relapsing polychondritis was diagnosed. Ga-67 citrate scintigraphy was preformed to determine the optimum biopsy site of the cartilage. The diagnosis was histologically supported by the results of the open biopsy.
In this case, Tc-99m MDP bone scintigraphy was useful for diagnosing relapsing polychondritis, and Ga-67 citrate scintigraphy was helpful in determining the biopsy site.
复发性多软骨炎是一种累及关节、气管、支气管、喉软骨、肋软骨以及耳和鼻软骨的全身性复发性软骨疾病。它与自身免疫性疾病相关，在某些情况下包括桥本氏病。
作者评估了一名29岁的复发性多软骨炎男性患者，该患者有2个月的普通感冒症状和体征，以及1个月的胸骨附近前胸疼痛。
诊断后，作者发现该患者15年前有过因甲状腺功能亢进接受甲状腺治疗的病史。为评估前胸疼痛而进行的锝-99m亚甲基二膦酸盐（Tc-99m MDP）骨闪烁显像显示，所有肋软骨和胸锁关节放射性摄取弥漫性增加。基于这些信息，诊断为复发性多软骨炎。进行了枸橼酸镓-67（Ga-67）闪烁显像以确定软骨的最佳活检部位。开放活检结果在组织学上支持了该诊断。
在该病例中，Tc-99m MDP骨闪烁显像对复发性多软骨炎的诊断有用，而Ga-67枸橼酸闪烁显像有助于确定活检部位。
