Benoni G
Ortopediska kliniken, Universitetssjukhuset MAS, Malmö.
Lakartidningen. 1999 Jun 16;96(24):2967-9.
Blood loss in total knee arthroplasty is some-times profuse and often necessitates transfusion which is associated with a risk of disease transmission and immunological burden to the recipient. The fibrinolytic system is activated during surgery, an activation augmented by the tourniquet often used in knee arthroplasty. We have found tranexamic acid, a well-known fibrinolytic inhibitor, to reduce blood loss by half in total knee arthroplasty, and the need of transfusion by two thirds. For optimal efficacy, the tranexamic acid should be administered as prophylaxis before release of the tourniquet. We have found no adverse effects of the drug.
全膝关节置换术中失血有时很多，常常需要输血，而输血与疾病传播风险以及受血者的免疫负担相关。纤溶系统在手术过程中被激活，而膝关节置换术中常用的止血带会加剧这种激活。我们发现，知名的纤溶抑制剂氨甲环酸可使全膝关节置换术中的失血量减少一半，并使输血需求减少三分之二。为达到最佳疗效，氨甲环酸应在松开止血带前作为预防性用药使用。我们未发现该药物有不良反应。
