Division of Orthopaedic Surgery, Toronto Western Hospital, Toronto, Ontario, Canada.
J Arthroplasty. 2014 Apr;29(4):681-4. doi: 10.1016/j.arth.2013.09.005. Epub 2013 Oct 4.
The efficaciousness of topical tranexamic acid use at the end of knee arthroplasty surgery to reduce blood loss and transfusion requirements has previously been shown. The aim of this study was to retrospectively assess the effectiveness of topical tranexamic acid use, comparing 155 patients undergoing hip and knee arthroplasty surgery in which tranexamic acid was routinely used, to a group of 149 patients from a similar time frame prior to the introduction of tranexamic acid use. The transfusion rate fell from 19.3% to 2.3% for hip arthroplasty patients and from 13.1% to 0% for knee arthroplasty patients; these differences were significant. We also found significant reductions in haemoglobin loss, blood loss and length of stay of 8 g/L, 244 mL and 1.0 days respectively for hip arthroplasties and 15 g/L, 527 mL and 1.2 days respectively for knee arthroplasties following the introduction of tranexamic acid.
局部使用氨甲环酸可减少膝关节置换术结束时的失血量和输血需求，这已得到证实。本研究旨在回顾性评估局部使用氨甲环酸的效果，比较了常规使用氨甲环酸的 155 例髋关节和膝关节置换术患者与在引入氨甲环酸之前的类似时间段的 149 例患者。髋关节置换术患者的输血率从 19.3%降至 2.3%，膝关节置换术患者的输血率从 13.1%降至 0%；这些差异具有统计学意义。我们还发现，引入氨甲环酸后，髋关节置换术患者的血红蛋白丢失、失血量和住院时间分别减少了 8 g/L、244 mL 和 1.0 天，膝关节置换术患者的血红蛋白丢失、失血量和住院时间分别减少了 15 g/L、527 mL 和 1.2 天。
