静脉注射免疫球蛋白对一名患有普秃的常见可变免疫缺陷患者毛发再生的影响。
Effect of IVIG on the hair regrowth in a common variable immune deficiency patient with alopecia universalis.
作者信息
Boonyaleepun S, Boonyaleepun C, Schlactus J L
机构信息
Department of Pediatrics, University of Tennessee Medical Center, Knoxville, USA.
出版信息
Asian Pac J Allergy Immunol. 1999 Mar;17(1):59-62.
Common variable immune deficiency (CVID) is associated with a variety of autoimmune diseases. Alopecia universalis (AU), believed to have an autoimmune basis, has been found in 1.6% of patients with CVID. Intravenous immunoglobulin (IVIG) therapy is used in various immunodeficiency disorders including CVID, and benefit has been shown in the therapy of autoimmune diseases. We report a patient with CVID and AU treated with IVIG who experienced significant hair regrowth. An 8-year-old girl with CVID and AU was treated with IVIG 400 mg/kg every 4 weeks. Since her second dose of IVIG, regrowth of eyelashes, eyebrows, body and scalp hair was observed in this patient. At present, about 1 year treat-meant of IVIG, significant hair regrowth is noted with 5-6 cm of scalp hair. We believe that IVIG may be beneficial in the treatment of AU, at least in patients with CVID.
普通可变免疫缺陷（CVID）与多种自身免疫性疾病相关。全秃（AU）被认为具有自身免疫基础，在1.6%的CVID患者中被发现。静脉注射免疫球蛋白（IVIG）疗法用于包括CVID在内的各种免疫缺陷疾病，并且已显示其在自身免疫性疾病治疗中有益处。我们报告一名接受IVIG治疗的CVID和AU患者，其毛发显著再生。一名患有CVID和AU的8岁女孩每4周接受400mg/kg的IVIG治疗。自她第二次注射IVIG以来，该患者的睫毛、眉毛、身体和头皮毛发开始再生。目前，在接受约1年的IVIG治疗后，头皮毛发显著再生，长度达5 - 6厘米。我们认为IVIG可能对AU的治疗有益，至少对CVID患者有益。
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