Haque R, Ali I M, Petri W A
International Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Am J Trop Med Hyg. 1999 Jun;60(6):1031-4. doi: 10.4269/ajtmh.1999.60.1031.
Entamoeba histolytica infection was present in 5% and E. dispar in 13% of asymptomatic 2-5-year-old children from an urban slum of Dhaka, Bangladesh. Entamoeba dispar-infected children were no more likely than uninfected children to have serum antibodies to lectin. In contrast, all children infected with E. histolytica had serum antibodies to lectin. This anti-lectin response included antibodies against the carbohydrate recognition domain, which have been demonstrated in animal models to confer passive protection from amebiasis. Antibodies to lectin persisted in the sera of 17 children with E. histolytica infection over one year of follow-up, during which time E. histolytica infection cleared without treatment in 15, and with anti-amebic medication in two. We conclude that half of the children in this population have serologic evidence of amebiasis by five years of age, and that an anti-lectin serum antibody response is associated with limitation of E. histolytica infection to the colon.
在孟加拉国达卡一个城市贫民窟中，2至5岁无症状儿童里，溶组织内阿米巴感染率为5%，迪氏内阿米巴感染率为13%。感染迪氏内阿米巴的儿童产生凝集素血清抗体的可能性并不高于未感染儿童。相比之下，所有感染溶组织内阿米巴的儿童都有凝集素血清抗体。这种抗凝集素反应包括针对碳水化合物识别结构域的抗体，在动物模型中已证明这些抗体可提供对阿米巴病的被动保护。17名感染溶组织内阿米巴的儿童在长达一年的随访期间，其血清中凝集素抗体持续存在，在此期间，15名儿童未经治疗溶组织内阿米巴感染自行清除，2名儿童接受了抗阿米巴药物治疗。我们得出结论，该人群中一半的儿童在5岁时就有阿米巴病的血清学证据，并且抗凝集素血清抗体反应与溶组织内阿米巴感染局限于结肠有关。
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