Gilchrist Carol A, Petri Sarah E, Schneider Brittany N, Reichman Daniel J, Jiang Nona, Begum Sharmin, Watanabe Koji, Jansen Caroline S, Elliott K Pamela, Burgess Stacey L, Ma Jennie Z, Alam Masud, Kabir Mamun, Haque Rashidul, Petri William A
Department of Medicine.
International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
J Infect Dis. 2016 May 15;213(10):1579-85. doi: 10.1093/infdis/jiv772. Epub 2015 Dec 27.
An estimated 1 million children die each year before their fifth birthday from diarrhea. Previous population-based surveys of pediatric diarrheal diseases have identified the protozoan parasite Entamoeba histolytica, the etiological agent of amebiasis, as one of the causes of moderate-to-severe diarrhea in sub-Saharan Africa and South Asia.
We prospectively studied the natural history of E. histolytica colonization and diarrhea among infants in an urban slum of Dhaka, Bangladesh.
Approximately 80% of children were infected with E. histolytica by the age of 2 years. Fecal anti-galactose/N-acetylgalactosamine lectin immunoglobulin A was associated with protection from reinfection, while a high parasite burden and expansion of the Prevotella copri level was associated with diarrhea.
E. histolytica infection was prevalent in this population, with most infections asymptomatic and diarrhea associated with both the amount of parasite and the composition of the microbiota.
据估计，每年有100万儿童在5岁前死于腹泻。以往基于人群的小儿腹泻病调查已确定，阿米巴病的病原体——原生动物寄生虫溶组织内阿米巴是撒哈拉以南非洲和南亚中度至重度腹泻的病因之一。
我们对孟加拉国达卡一个城市贫民窟的婴儿中溶组织内阿米巴定植和腹泻的自然史进行了前瞻性研究。
到2岁时，约80%的儿童感染了溶组织内阿米巴。粪便抗半乳糖/N-乙酰半乳糖胺凝集素免疫球蛋白A与预防再次感染有关，而高寄生虫负荷和普氏粪杆菌水平的升高与腹泻有关。
溶组织内阿米巴感染在该人群中很普遍，大多数感染无症状，腹泻与寄生虫数量和微生物群组成有关。
