Bax表达降低与口腔和口咽癌的不良预后相关。

Decreased expression of Bax is correlated with poor prognosis in oral and oropharyngeal carcinoma.

作者信息

Ito T, Fujieda S, Tsuzuki H, Sunaga H, Fan G, Sugimoto C, Fukuda M, Saito H

机构信息

Department of Otorhinolaryngology, Fukui Medical University, Matsuoka, Yoshida, Japan.

出版信息

Cancer Lett. 1999 Jun 1;140(1-2):81-91. doi: 10.1016/s0304-3835(99)00055-5.

DOI:10.1016/s0304-3835(99)00055-5

PMID:10403545

Abstract

We investigated the expression of apoptosis-related factors, p53, Bax, Bcl-2, and spontaneous apoptosis in 57 cases of oral and oropharyngeal squamous cell carcinoma (SCC) by immunochemical staining and ApopTag kit. Positive expression of Bax was inversely associated with advanced tumor stage (P = 0.0225), lymph node metastasis (P = 0.0225), clinical stage (P = 0.0083) and poor prognosis (P = 0.0478). Positive expression of p53 was related to poor prognosis (P = 0.0445) and was associated with negative expression of Bax (P = 0.0439). The apoptosis index did not correlate with clinical outcome. These results suggest that abnormality of Bax expression plays an important role in tumor progression in oral and oropharyngeal SCC.

摘要

我们通过免疫化学染色和ApopTag试剂盒，研究了57例口腔和口咽鳞状细胞癌（SCC）中凋亡相关因子p53、Bax、Bcl-2的表达及自发凋亡情况。Bax的阳性表达与肿瘤晚期（P = 0.0225）、淋巴结转移（P = 0.0225）、临床分期（P = 0.0083）及预后不良（P = 0.0478）呈负相关。p53的阳性表达与预后不良相关（P = 0.0445），且与Bax的阴性表达相关（P = 0.0439）。凋亡指数与临床结果无关。这些结果表明，Bax表达异常在口腔和口咽SCC的肿瘤进展中起重要作用。