Kobe N, Takamatsu J, Ito M, Sakane S, Ohsawa N
First Department of Medicine, Osaka Medical College, Takatsuki, Japan.
Endocrine. 1999 Feb;10(1):53-6. doi: 10.1385/ENDO:10:1:53.
There have been few studies on acute changes of bone metabolism in humans by thyroid hormone. This study aimed to examine the effects of triiodothyronine on serum markers of bone and mineral metabolism during a 7-d course of daily 75 microg therapy in 14 normal volunteers by drawing blood on 1, 2, 3, 5, and 7 d of therapy. Serum calcium concentrations did not significantly change during the course of therapy, while serum phosphorus concentrations were significantly (p < 0.05) decreased from 3.21 +/- 0.43 mg/dL (mean +/- SD) to 2.85 +/- 0.46 mg/dL on the 7th d. Serum PTH concentrations were significantly decreased from 339 +/- 116 pg/mL to 316 +/- 29 pg/mL. Serum concentrations of alkali-phosphatase and bone-specific alkali-phosphatase were not significantly changed, but serum osteocalcin concentrations were significantly increased from 5.71 +/- 1.98 mg/dL to 6.73 +/- 2.24 mg/dL. Serum carboxy-terminal propeptide of type I collagen concentrations were significantly decreased from 137.8 +/- 33.7 microg/L to 119.2 +/- 33.6 microg/L. Serum pyridinoline cross-linked telopeptide domain of type I collagen concentrations, a bone resorption marker, were significantly increased from 3.40 +/- 0.77 to 3.87 +/- 1.05 microg/L, and such significant increase was obtained from the 3rd day. The results indicate that some of bone and mineral markers change rapidly in response to triiodothyronine-induced acute thyrotoxicosis, but the manner of change is not the same as that of chronic thyrotoxicosis.
关于甲状腺激素对人体骨代谢急性变化的研究较少。本研究旨在通过对14名正常志愿者进行为期7天、每日75微克三碘甲状腺原氨酸治疗，并在治疗的第1、2、3、5和7天采血，来检测三碘甲状腺原氨酸对骨和矿物质代谢血清标志物的影响。治疗过程中血清钙浓度无显著变化，而血清磷浓度在第7天从3.21±0.43毫克/分升降至2.85±0.46毫克/分升，显著降低（p<0.05）。血清甲状旁腺激素浓度从339±116皮克/毫升显著降至316±29皮克/毫升。血清碱性磷酸酶和骨特异性碱性磷酸酶浓度无显著变化，但血清骨钙素浓度从5.71±1.98毫克/分升显著增至6.73±2.24毫克/分升。血清I型胶原羧基末端前肽浓度从137.8±33.7微克/升显著降至119.2±33.6微克/升。作为骨吸收标志物的血清I型胶原吡啶啉交联端肽结构域浓度从3.40±0.77微克/升显著增至3.87±1.05微克/升，且从第3天起就出现了这种显著增加。结果表明，一些骨和矿物质标志物会因三碘甲状腺原氨酸诱导的急性甲状腺毒症而迅速变化，但变化方式与慢性甲状腺毒症不同。
