Wierrani F, Kubin A, Jindra R, Henry M, Gharehbaghi K, Grin W, Söltz-Szötz J, Alth G, Grünberger W
Department of Obstetrics and Gynecology, Rudolfstiftung Hospital, Vienna, Austria.
Cancer Detect Prev. 1999;23(4):351-5. doi: 10.1046/j.1525-1500.1999.99036.x.
The aim of this study was to treat patients for ectocervical dysplasia [cervical intraepithelial neoplasia (CIN) grades 1 and 2] and associated human papilloma virus (HPV) infections with photodynamic therapy (PDT). In 20 patients, 5-aminolevulinic acid (5-ALA, 12% w/v) was applied topically with a cervical cap 8 h prior to illumination. A thermal light source (150 W halogen lamp) emitting a broadband red light (total energy: 100 J/cm2, fluence rate: 90 mW/cm2) was used for superficial illumination of the portio. In addition, an Nd:YAG pumped dye laser (652 nm) was used to illuminate the cervical canal (total energy: 50 J/cm2, fluence rate: 300 mW/cm2). Preliminary results of follow-ups at 1, 3, 6, and 9 months posttherapy showed a cytological improvement in the grading of the PAP smears in 19 patients and the eradication of cervical HPV in 80%. These results demonstrate that ectocervical dysplasia and associated HPV infections can be treated by PDT.
本研究的目的是用光动力疗法（PDT）治疗宫颈外翻发育异常[宫颈上皮内瘤变（CIN）1级和2级]及相关的人乳头瘤病毒（HPV）感染。20例患者在光照前8小时用宫颈帽局部涂抹5-氨基酮戊酸（5-ALA，12% w/v）。使用发出宽带红光的热光源（150 W卤素灯）（总能量：100 J/cm²，能量通量率：90 mW/cm²）对宫颈阴道部进行表面照射。此外，使用Nd:YAG泵浦染料激光器（652 nm）照射宫颈管（总能量：50 J/cm²，能量通量率：300 mW/cm²）。治疗后1、3、6和9个月的初步随访结果显示，19例患者巴氏涂片分级在细胞学上有所改善，80%的患者宫颈HPV被清除。这些结果表明，宫颈外翻发育异常及相关HPV感染可用PDT治疗。
