Jolly C A, Fernandes G
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7874, USA.
J Clin Immunol. 1999 May;19(3):172-8. doi: 10.1023/a:1020503727157.
Calorie restriction or fish oil extends life span. To investigate the potential mechanism(s) involved, young (4-month) and old (9-month) NZB x NZW(F1) mice were fed 5% (w/w) corn oil (CA) or fish oil (FA) ad libitum or 40% restricted (CR and FR, respectively). Peripheral blood T-lymphocytes were analyzed for Th-1 (IL-2, IFN-gamma) and Th-2 (IL-5, IL-10) production. CR and FA partially blunted while FR completely abolished the decline in aged CD4+ T lymphocytes. In contrast, both CR and FR abolished the decline in CD8+ T lymphocytes with age, while FA had no effect. In aged mice, both CR and FR blunted the increase in Th-1 (IL-2, IFN-gamma) cytokine production, while FA was only partially effective. Only FR completely blunted the age-related increase in Th-2 (IL-5, IL-10) cytokine production. These data suggest that FR delays the onset of autoimmune kidney disease by suppressing both Th-1 and Th-2 cytokine production.
热量限制或鱼油可延长寿命。为了研究其中潜在的机制，给年轻（4个月）和年老（9个月）的新西兰黑鼠与新西兰白鼠（F1）自由喂食5%（重量/重量）玉米油（CA）或鱼油（FA），或者分别进行40%的热量限制（分别为CR和FR）。分析外周血T淋巴细胞中Th-1（白细胞介素-2、干扰素-γ）和Th-2（白细胞介素-5、白细胞介素-10）的产生情况。CR和FA部分抑制了衰老CD4 + T淋巴细胞数量的下降，而FR则完全消除了这种下降。相反，CR和FR都消除了CD8 + T淋巴细胞数量随年龄的下降，而FA没有效果。在年老小鼠中，CR和FR都抑制了Th-1（白细胞介素-2、干扰素-γ）细胞因子产生的增加，而FA只是部分有效。只有FR完全抑制了Th-2（白细胞介素-5、白细胞介素-10）细胞因子产生随年龄的增加。这些数据表明，FR通过抑制Th-1和Th-2细胞因子的产生来延迟自身免疫性肾病的发病。
