Wøjdemann M, Wettergren A, Hartmann B, Hilsted L, Holst J J
Department of Surgery, Rigshospitalet, Copenhagen, Denmark.
J Clin Endocrinol Metab. 1999 Jul;84(7):2513-7. doi: 10.1210/jcem.84.7.5840.
Glucagon-like peptide (GLP)-2 is formed from proglucagon in the intestinal L cells and is secreted postprandially in parallel with the insulinotropic hormone GLP-1, the latter of which, in addition, acts to inhibit gastric secretion and motility by inhibiting central parasympathetic outflow. We now studied the effect of GLP-2 on gastric secretion stimulated by sham feeding to test the hypothesis that also GLP-2 acts as an enterogastrone. Eight healthy volunteers were studied twice on separate days. They were sham fed with and without GLP-2 infused iv at a rate of 0.8 pmol/kg x min. Gastric contents were aspirated continuously by a nasogastric tube for determination of acid secretion, volume, and osmolarity. Sham feeding increased gastric acid secretion nearly 5-fold. Infusion of GLP-2 reduced incremental acid secretion by 65+/-6%, compared with saline infusion (delta8.75+/-0.37 vs. delta3.04+/-0.47 mmol x 60 min; P<0.01). Plasma concentrations of GLP-2 rose from a basal mean of 3.3+/-0.9 to a mean of 115+/-8 pmol/L (range, 57-149 pmol/L) during infusion of GLP-2 and remained at basal level during saline infusion. Plasma concentrations of GLP-1, gastrin, cholecystokinin, and secretin remained low and unchanged on both study days. We conclude that GLP-2 is a powerful inhibitor of gastric acid secretion in man. Further investigations will show to what extent GLP-2 contributes to the inhibitory effects on gastric secretion exerted by hormones from the distal small intestine, under physiological circumstances.
胰高血糖素样肽（GLP）-2由肠道L细胞中的胰高血糖素原生成，在餐后与促胰岛素激素GLP-1一同分泌，此外，GLP-1还通过抑制中枢副交感神经传出神经来抑制胃酸分泌和胃动力。我们现在研究了GLP-2对假饲刺激的胃酸分泌的影响，以验证GLP-2也作为一种肠抑胃素的假说。8名健康志愿者在不同日期接受了两次研究。他们在静脉输注或不输注GLP-2（速率为0.8 pmol/kg×min）的情况下进行假饲。通过鼻胃管持续抽吸胃内容物，以测定胃酸分泌、容量和渗透压。假饲使胃酸分泌增加近5倍。与输注生理盐水相比，输注GLP-2使胃酸分泌增量减少65±6%（分别为8.75±0.37 mmol×60 min和3.04±0.47 mmol×60 min；P<0.01）。在输注GLP-2期间，血浆GLP-2浓度从基础平均值3.3±0.9升高至平均值115±8 pmol/L（范围为57 - 149 pmol/L），而在输注生理盐水期间保持在基础水平。在两个研究日，血浆GLP-1、胃泌素、胆囊收缩素和促胰液素浓度均保持较低且无变化。我们得出结论，GLP-2是人体胃酸分泌的强效抑制剂。进一步的研究将表明，在生理情况下，GLP-2在多大程度上对远端小肠激素对胃酸分泌的抑制作用有贡献。
