Hill S Y, Locke J, Lowers L, Connolly J
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA.
J Am Acad Child Adolesc Psychiatry. 1999 Jul;38(7):883-91. doi: 10.1097/00004583-199907000-00019.
To compare rates of psychopathology and academic achievement in children who were either at high or low risk for developing alcoholism and to determine whether academic deficits would predict prospectively the presence of psychopathology occurring within the next year.
Children and adolescents, aged 8 to 18 years, were evaluated as part of a longitudinal follow-up. Diagnoses obtained by using the Schedule for Affective Disorders and Schizophrenia for School-Age Children and grade-equivalent scores from the reading, spelling, and arithmetic sections of the Wide Range Achievement Test were determined at yearly intervals.
High-risk offspring were more likely to have a diagnosable disorder. In addition, analyses using the mother's and father's diagnosis of alcoholism as a covariate showed higher hazard ratios for selected disorders (depression, affective disorder, attention-deficit/hyperactivity disorder, and conduct disorder), some of which were gender-dependent. Logistic regression analysis of achievement test scores demonstrated that reading and math scores predicted the presence of childhood psychopathology at the following annual evaluation.
Children from pedigrees with a high density of alcoholism are at greater risk for developing psychopathology. Furthermore, observed deficits in academic performance may be considered an indicator of a developing diagnosable illness.
比较患酒精中毒高风险和低风险儿童的精神病理学发生率及学业成绩,并确定学业缺陷是否能前瞻性地预测下一年出现的精神病理学情况。
对8至18岁的儿童和青少年进行评估,作为纵向随访的一部分。每年使用儿童情感障碍和精神分裂症检查表进行诊断,并确定广泛成就测验阅读、拼写和算术部分的年级当量分数。
高风险后代更有可能患有可诊断的疾病。此外,将母亲和父亲的酒精中毒诊断作为协变量进行分析,结果显示某些特定疾病(抑郁症、情感障碍、注意力缺陷/多动障碍和品行障碍)的风险比更高,其中一些疾病存在性别差异。对成绩测验分数进行逻辑回归分析表明,阅读和数学分数可预测下一年度评估时儿童精神病理学的存在情况。
来自酗酒密度高的家族的儿童患精神病理学的风险更大。此外,观察到的学业成绩缺陷可能被视为正在发展的可诊断疾病的一个指标。