构象受限的选择性基质金属蛋白酶抑制剂的合成与鉴定
Synthesis and identification of conformationally constrained selective MMP inhibitors.
作者信息
Freskos J N, McDonald J J, Mischke B V, Mullins P B, Shieh H S, Stegeman R A, Stevens A M
机构信息
Department of Medicinal Chemistry, Searle Discovery Research, St Louis, MO 63198, USA.
出版信息
Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. doi: 10.1016/s0960-894x(99)00285-1.
Abstract
We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1.
摘要
我们发现了一系列新的强效构象受限的基质金属蛋白酶（MMP）抑制剂，它们对MMP-13的选择性高于MMP-1。
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