Design and synthesis of conformationally-constrained MMP inhibitors.

作者信息

Natchus M G, Cheng M, Wahl C T, Pikul S, Almstead N G, Bradley R S, Taiwo Y O, Mieling G E, Dunaway C M, Snider C E, McIver J M, Barnett B L, McPhail S J, Anastasio M B, De B

机构信息

Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA.

出版信息

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. doi: 10.1016/s0960-894x(98)00370-9.

DOI:10.1016/s0960-894x(98)00370-9

PMID:9873489

Abstract

A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.

摘要

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