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[鼻硬结病:一例报告]

[Rhinoscleroma: a case report].

作者信息

Issing W J, Bodlaj R

机构信息

Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke, Ludwig-Maximilians Universität München.

出版信息

Laryngorhinootologie. 1999 Apr;78(4):200-3. doi: 10.1055/s-2007-996857.

Abstract

BACKGROUND

Rhinoscleroma is a rare infectious disease of the upper respiratory tract caused by Klebsiella rhinoscleromatis. The nasal mucosa represents the primary region of occurrence which is most likely a result of respiratory transmission. Without adequate++ treatment, the disease can potentially spread to the rest of the upper and middle respiratory tract within a period of several years. Healing often occurs with extensive scarring and adhesions of the nose, palate and larynx. A life threatening late stage manifestation includes subglottic stenosis requiring immediate surgical intervention. Medical treatment primarily consists of a long-term course of antibiotics. Ciprofloxacin (Fluoroquinolon) has proved to be one of the most effective drugs.

CASE REPORT

We report about a 33 year-old Egyptian male, who presented in our department with a 10 year history of a previously, only temporarily successfully treated rhinoscleroma. His main symptoms were nasal obstruction, epistaxis and inspiratory stridor.

FINDINGS

We began treatment with Ciprofloxacin over a four week period, which lead to an improvement of his symptoms. The treatment was considered complete after several biopsies and smears were negative for live specimens. We then chose to reduce the scar tissue that was causing obstruction in the larynx and the nose.

CONCLUSION

The rhinoscleroma is a rare disease in geographic areas with poor hygiene and can mimic several other infectious and malignant diseases. Treatment should include a long-term antimicrobial therapy and surgical intervention in cases with symptomatic obstruction.

摘要

背景

鼻硬结病是一种由鼻硬结克雷伯菌引起的上呼吸道罕见传染病。鼻粘膜是主要发病部位,很可能是通过呼吸道传播所致。若未得到充分治疗,该病可能在数年内扩散至整个上呼吸道和中呼吸道。愈合时常常伴有鼻子、腭和喉部的广泛瘢痕形成和粘连。一种危及生命的晚期表现为声门下狭窄,需要立即进行手术干预。药物治疗主要是长期使用抗生素。环丙沙星(氟喹诺酮类)已被证明是最有效的药物之一。

病例报告

我们报告一例33岁的埃及男性,他到我们科室就诊,有10年鼻硬结病史,之前治疗仅暂时成功。他的主要症状是鼻塞、鼻出血和吸气性喘鸣。

检查结果

我们开始用环丙沙星治疗四周,这使他的症状有所改善。在多次活检和涂片未发现活标本后,认为治疗完成。然后我们选择减少导致喉部和鼻子阻塞的瘢痕组织。

结论

鼻硬结病在卫生条件差的地区是一种罕见疾病,可类似其他几种感染性和恶性疾病。治疗应包括长期抗菌治疗以及对有症状性阻塞的病例进行手术干预。

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