National Skin Centre, 1 Mandalay Road, Singapore.
Singapore Med J. 2012 Feb;53(2):e24-7.
Rhinoscleroma is a chronic, slowly progressive, inflammatory disease of the upper respiratory tract. It is associated with Klebsiella rhinoscleromatis infection. We present the clinical and pathological features of four patients diagnosed with rhinoscleroma at the National Skin Centre, Singapore between 1997 and 2010. All four patients presented with only cutaneous involvement, and the diagnosis was clinched via histological examination. The patients were treated with a combination of antibiotics. Two patients who were on follow-up at the time of this writing responded positively to the antibiotic treatment, while two were lost to follow-up. Rhinoscleroma is a diagnostic challenge, as it is an uncommon disease in Singapore and Malaysia. We highlight this condition to raise awareness of the disease in order to aid in early diagnosis of patients. Without treatment, this condition can result in significant complications, including involvement of the lower airways. Early diagnosis and appropriate treatment help to reduce morbidity.
类肉瘤病是一种慢性、缓慢进展的上呼吸道炎症性疾病。它与鼻疽伯克霍尔德菌感染有关。我们在新加坡国家皮肤中心报告了 1997 年至 2010 年间诊断的 4 例类肉瘤病患者的临床和病理特征。所有 4 例患者均仅表现为皮肤受累，通过组织学检查确诊。患者接受了抗生素联合治疗。在本次研究进行时正在接受随访的 2 例患者对抗生素治疗反应良好，而 2 例患者失访。类肉瘤病是一种诊断上的挑战，因为它在新加坡和马来西亚并不常见。我们强调这种疾病是为了提高对该病的认识，以帮助早期诊断患者。如果不治疗，这种疾病可能会导致严重的并发症，包括下呼吸道受累。早期诊断和适当的治疗有助于降低发病率。
