Ghezzo F, Berta G N, Bussolati B, Bosio A, Corvetti G, Di Carlo F, Bussolati G, Guglielmone R, Bartorelli A
Department of Biological Science, University of Turin, Italy.
Br J Cancer. 1999 Jan;79(1):54-8. doi: 10.1038/sj.bjc.6690011.
Chemically induced Syrian hamster cheek-pouch squamous cell carcinoma is very similar to the corresponding human tumour. This paper describes a blind study in which inhibition of dimethylbenzanthracene-induced cheek-pouch tumours by a goat liver extract denominated UK101 was investigated. Less than 40% of animals treated with UK101 developed tumours compared with 100% of the controls. Intermediate results (80%) were noted in a positive control group treated with Calmette-Guerin bacillus. Immunocytochemical testing of cheek-pouch mucosa by Mib5 showed significantly less proliferating cells in UK101 animals than in the controls. The effect of UK101 was completely reversed when dexamethasone was added in a third control group. A significant difference in complement-mediated cytotoxicity was noted in the sera of UK101-tested and control animals. These findings suggest that an immune mechanism is responsible for the inhibition of hamster cheek-pouch carcinoma by UK101.
化学诱导的叙利亚仓鼠颊囊鳞状细胞癌与相应的人类肿瘤非常相似。本文描述了一项盲法研究，该研究调查了一种名为UK101的山羊肝提取物对二甲基苯并蒽诱导的颊囊肿瘤的抑制作用。与100%的对照组相比，用UK101治疗的动物中不到40%发生了肿瘤。在用卡介苗治疗的阳性对照组中观察到中间结果（80%）。通过Mib5对颊囊黏膜进行免疫细胞化学检测发现，与对照组相比，UK101处理的动物中增殖细胞明显减少。当在第三个对照组中加入地塞米松时，UK101的作用完全逆转。在接受UK101检测的动物和对照动物的血清中，补体介导的细胞毒性存在显著差异。这些发现表明，免疫机制是UK101抑制仓鼠颊囊癌的原因。
