MLL2：trx/MLL基因家族的一个新的哺乳动物成员。

MLL2: A new mammalian member of the trx/MLL family of genes.

作者信息

FitzGerald K T, Diaz M O

机构信息

Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, USA.

出版信息

Genomics. 1999 Jul 15;59(2):187-92. doi: 10.1006/geno.1999.5860.

DOI:10.1006/geno.1999.5860

PMID:10409430

Abstract

We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded.

摘要

我们在染色体带19q13.1上鉴定出一个与MLL密切相关的基因。MLL位于染色体11q23的一个区域，该区域与染色体19q有部分同线性。我们将位于19q13.1的这个基因命名为MLL2。MLL2编码一种蛋白质，该蛋白质在几个重要的蛋白质结构域上与MLL表现出高度相似性。MLL2在成人组织中也普遍表达，MLL也是如此。MLL是果蝇基因三体胸节（trx）的同源物，trx编码一种同源异型基因表达的调节因子。MLL参与哺乳动物中与白血病相关的染色体重排。然而，尚未记录到与白血病相关的MLL2重排。