Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France.
EPIGENEXP Platform, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France.
Int J Mol Sci. 2020 Oct 14;21(20):7571. doi: 10.3390/ijms21207571.
Due to the spectacular number of studies focusing on epigenetics in the last few decades, and particularly for the last few years, the availability of a chronology of epigenetics appears essential. Indeed, our review places epigenetic events and the identification of the main epigenetic writers, readers and erasers on a historic scale. This review helps to understand the increasing knowledge in molecular and cellular biology, the development of new biochemical techniques and advances in epigenetics and, more importantly, the roles played by epigenetics in many physiological and pathological situations.
由于过去几十年中大量研究集中在表观遗传学上,尤其是过去几年,因此提供一个表观遗传学的时间轴似乎是必要的。事实上,我们的综述将表观遗传事件和主要的表观遗传写入器、读取器和擦除器的鉴定置于历史尺度上。这篇综述有助于理解分子和细胞生物学中不断增加的知识,新的生化技术的发展以及表观遗传学的进步,更重要的是,了解表观遗传学在许多生理和病理情况下所扮演的角色。