Marken Lichtenbelt W D, Fogelholm M
Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands.
J Appl Physiol (1985). 1999 Jul;87(1):294-8. doi: 10.1152/jappl.1999.87.1.294.
The hydration of fat free mass (FFM) and extracellular (ECW) and intracellular water (ICW) compartments were studied in 30 obese premenopausal women before and after a 3-mo weight-reduction program and again after a 9-mo weight-maintenance program. Body fat was determined by a four-compartment model. Total body water and ECW were determined by deuterium dilution and bromide dilution, respectively. After the weight-reduction period, mean weight loss was 12.8 kg, and body fat was reduced on average by 10.9 kg. During weight maintenance, changes in body mass and body fat were not significant. Before weight reduction, mean ECW/ICW ratio was relatively high (0.78 +/- 0.10). During the the study, total body water and ICW did not change significantly. ECW did not change significantly after weight reduction, but 12 mo after the start ECW was significantly increased by 1 liter. The ECW/ICW ratio increased to 0.87 +/- 0.12 (month 12). The hydration of the FFM increased from 74 +/- 1 to 77 +/- 2% during the weight reduction and remained elevated during weight maintenance. In conclusion, the ECW/ICW ratio and the hydration of the FFM, did not normalize during weight reduction and weight maintenance.
在一项为期3个月的减重计划前后以及9个月的体重维持计划后，对30名肥胖的绝经前女性的去脂体重（FFM）、细胞外液（ECW）和细胞内液（ICW）的水合作用进行了研究。通过四室模型测定体脂。分别通过氘稀释法和溴化物稀释法测定总体水和ECW。在减重期后，平均体重减轻12.8千克，体脂平均减少10.9千克。在体重维持期间，体重和体脂的变化不显著。在减重前，平均ECW/ICW比值相对较高（0.78±0.10）。在研究期间，总体水和ICW没有显著变化。减重后ECW没有显著变化，但在开始后的12个月时，ECW显著增加了1升。ECW/ICW比值增加到0.87±0.12（第12个月）。FFM的水合作用在减重期间从74±1%增加到77±2%，并在体重维持期间保持升高。总之，在减重和体重维持期间，ECW/ICW比值和FFM的水合作用并未恢复正常。
