Valenti R, Motta A, Merlini S, Morisetti A, Tirone P
Milan Research Centre of Bracco, Italy.
Acad Radiol. 1999 Jul;6(7):426-32. doi: 10.1016/s1076-6332(99)80193-7.
The purpose of this study was to determine the anticoagulant and antiplatelet characteristics of iopiperidol, a nonionic, triiodinated contrast agent.
Anticoagulant effects of iopiperidol were assessed both in vitro and in vivo after single or repeated intravenous administrations to rats. To this aim, results of prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen tests were evaluated. To define better the mechanism of action of iopiperidol and of the contrast media used for comparison, in vitro tests to study the effects on thrombin activity and on thrombin generation were performed. In addition, the effect of iopiperidol was studied on adenosine diphosphate- and collagen-induced platelet aggregation both in vitro and in vivo after single or repeated intravenous administrations in the rat.
In vitro, iopiperidol showed anticoagulant properties similar or superior to those of the ionic ioxaglate. Iopiperidol also inhibited collagen-induced platelet aggregation statistically significantly more than iodixanol and ioxaglate (P < .05). In vivo, no significant differences between iopiperidol and ioxaglate were observed after single or repeated administrations.
The in vitro anticoagulant effect of iopiperidol is similar or even superior to that of ioxaglate; the in vivo effect is similar to that of reference nonionic contrast media.
本研究旨在确定非离子型三碘造影剂碘哌醇的抗凝和抗血小板特性。
对大鼠单次或重复静脉注射碘哌醇后，在体外和体内评估其抗凝作用。为此，评估了凝血酶原时间、活化部分凝血活酶时间、凝血酶时间和纤维蛋白原检测结果。为了更好地确定碘哌醇及用于比较的造影剂的作用机制，进行了体外试验以研究其对凝血酶活性和凝血酶生成的影响。此外，在大鼠单次或重复静脉注射后，在体外和体内研究了碘哌醇对二磷酸腺苷和胶原诱导的血小板聚集的影响。
在体外，碘哌醇显示出与离子型碘克沙酸相似或更优的抗凝特性。碘哌醇对胶原诱导的血小板聚集的抑制作用在统计学上也显著强于碘克沙醇和碘克沙酸（P <.05）。在体内，单次或重复给药后，碘哌醇与碘克沙酸之间未观察到显著差异。
碘哌醇的体外抗凝作用与碘克沙酸相似甚至更优；体内作用与对照非离子型造影剂相似。
