Kurisu Y, Tada S
Department of Radiology, Jikei University School of Medicine, Tokyo, Japan.
Invest Radiol. 1992 Sep;27(9):686-8. doi: 10.1097/00004424-199209000-00005.
The anticoagulant effects of ionic and nonionic low-osmolar contrast media were evaluated in vivo.
The amount of clot deposited on guide wires placed in the femoral vessels of dogs was weighed 30 minutes after the injection of 2 mL/kg of different contrast media. Six dogs were examined after injection of ioxaglate (ioxaglate group), six after injection of iopamidol (iopamidol group), and five after injection of saline (saline group).
The mean weights of clot deposited on the guide wires in dogs in the ioxaglate group, the iopamidol group, and saline group were 30.5, 63.1, and 74.2 mg, respectively. The mean weight of clot deposition on the guide wires in the ioxaglate group was significantly less than in the iopamidol and saline groups, whereas there was no statistical difference in the mean weight of clot deposition on the guide wires in the iopamidol and saline groups.
Ioxaglate, a low-osmolar, ionic contrast medium, has a greater anticoagulant effect than a low-osmolar, nonionic contrast agent, such as iopamidol.
在体内评估离子型和非离子型低渗造影剂的抗凝作用。
在给犬注射2 mL/kg不同造影剂30分钟后，对置于股血管内的导丝上沉积的血凝块进行称重。注射碘克沙醇后检查6只犬（碘克沙醇组），注射碘帕醇后检查6只犬（碘帕醇组），注射生理盐水后检查5只犬（生理盐水组）。
碘克沙醇组、碘帕醇组和生理盐水组犬导丝上沉积血凝块的平均重量分别为30.5、63.1和74.2 mg。碘克沙醇组导丝上血凝块沉积的平均重量显著低于碘帕醇组和生理盐水组，而碘帕醇组和生理盐水组导丝上血凝块沉积的平均重量无统计学差异。
低渗离子型造影剂碘克沙醇比低渗非离子型造影剂如碘帕醇具有更强的抗凝作用。
