Fradelizi D
Unité Immunomodulation et Autoimmunité, INSERM U283, Hôpital Cochin, Paris, France.
Med Trop (Mars). 1998;58(4 Suppl):427-32.
Cytokines (cyto:cell; kine:factor) are produced by cells and serve as chemical messengers for one type of intracellular communication. Cytokines play a central role in host defense mechanisms. Defense against infectious and tumoral disease depends on nonspecific myelomonocyte defenses in conjunction with specific immune processes. Both systems are regulated by various leukocytes in the blood and tissue. All these cell components are produced in the bone marrow from hematopoietic stem cells. Cytokines are soluble messengers allowing deployment and coordination of all cell systems. Despite the complexity of the cytokine network, we now have a better understanding of the interactions between the different components determining secretion and activity of these mediators. This knowledge may hold the promise of better control of immune and inflammatory responses. Experimental data shows that the cytokine balance can be modulated in auto-immune, immune deficiency, and malignant diseases, opening up new perspectives for therapy and perhaps vaccination.
细胞因子（cyto：细胞；kine：因子）由细胞产生，作为一种细胞内通讯的化学信使。细胞因子在宿主防御机制中起核心作用。抵御感染性疾病和肿瘤疾病依赖于非特异性髓单核细胞防御以及特异性免疫过程。这两个系统均由血液和组织中的各种白细胞调节。所有这些细胞成分均由造血干细胞在骨髓中产生。细胞因子是可溶性信使，可实现所有细胞系统的部署和协调。尽管细胞因子网络很复杂，但我们现在对决定这些介质分泌和活性的不同成分之间的相互作用有了更好的理解。这一知识可能带来更好地控制免疫和炎症反应的希望。实验数据表明，在自身免疫性疾病、免疫缺陷疾病和恶性疾病中，细胞因子平衡可以被调节，为治疗甚至疫苗接种开辟了新的前景。
