Linares Santiago E, Gómez Parra M, Pellicer Bautista F, Romero Castro R, Caunedo Alvarez A, Mendoza Olivares F J, Catalán Ramírez J M, Herrerías Esteban J M, Rivera Hueto F, Herrerías Gutiérrez J M
Servicio de Aparato Digestivo, Hospital Universitario Virgen Macarena, Sevilla.
Gastroenterol Hepatol. 1999 Jun-Jul;22(6):273-8.
To evaluate the histopathological characteristics of colonic polyps, found during colonoscopy examination and endoscopic polypectomy, and their relation to age, tumor location, sex, histological type and degree of epithelial dysplasia.
Between 1996 and 1997, 2,465 total colonoscopies were performed at the Gastroenterology Department of the Virgin Macarena University Hospital in Seville. Different size polyps were found in 318 patients who had been referred because of several symptoms/by several centers. The mean age was 59.2 years in men and 61.5 years in women.
446 polyps were removed by endoscopic polypectomy, 32 (7.2%) were hyperplastic polyps, 402 were adenomas (90.2%) and 12 (2.6%) were adenomas with adenocarcinoma. Seventy-five percent of adenomas were located in the left colon and rectum and 25% in right colon. Hyperplastic polyps were found in left colon. Of the polyps removed, 55.1% were smaller than 1 cm, 26.5% were between 1 and 2 cm and 18.4% were between 2 and 7 cm. Histopathologic study of adenomas revealed that 17% were villous adenoma, 80% were tubular adenomas and 3% were tubulovillous adenomas. Adenocarcinomas were found in 12 (2.8%) adenomas. Of the adenomatous polyps, 87.4% had low-grade dysplasia and 12.6% high-grade dysplasia. Statistical analysis showed a strong correlation between size of adenoma and degree of dysplasia (p < 0.05). Similar significant relation was found between histological type and size (p < 0.05) but there were no statistically significant differences between location, sex or age, and degree of dysplasia (p < 0.05).
Size of colonic polyps is related to epithelial dysplasia and histological type (p < 0.05). No correlation was found between location, sex or age and degree of dysplasia.
评估结肠镜检查及内镜下息肉切除术中发现的结肠息肉的组织病理学特征，及其与年龄、肿瘤位置、性别、组织学类型和上皮发育异常程度的关系。
1996年至1997年间，塞维利亚圣母马卡雷纳大学医院胃肠病科共进行了2465例全结肠镜检查。在因多种症状被多个中心转诊的318例患者中发现了不同大小的息肉。男性的平均年龄为59.2岁，女性为61.5岁。
通过内镜下息肉切除术切除了446个息肉，其中32个（7.2%）为增生性息肉，402个（90.2%）为腺瘤，12个（2.6%）为伴有腺癌的腺瘤。75%的腺瘤位于左半结肠和直肠，25%位于右半结肠。增生性息肉见于左半结肠。切除的息肉中，55.1%小于1 cm，26.5%在1至2 cm之间，18.4%在2至7 cm之间。腺瘤的组织病理学研究显示，17%为绒毛状腺瘤，80%为管状腺瘤，3%为管状绒毛状腺瘤。在12个（2.8%）腺瘤中发现了腺癌。在腺瘤性息肉中，87.4%为低级别发育异常，12.6%为高级别发育异常。统计分析显示腺瘤大小与发育异常程度之间存在强相关性（p < 0.05）。在组织学类型与大小之间也发现了类似的显著关系（p < 0.05），但在位置、性别或年龄与发育异常程度之间未发现统计学上的显著差异（p < 0.05）。
结肠息肉的大小与上皮发育异常和组织学类型相关（p < 0.05）。在位置、性别或年龄与发育异常程度之间未发现相关性。
