Kulkarni M V, Kesavan V, Viswanathan G
Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Mumbai, India.
Indian J Biochem Biophys. 1998 Oct;35(5):303-7.
The two key enzymes, methylenetetrahydrofolate reductase and methionine synthase involved in methionine synthesis from homocysteine were studied in atherogenic diet fed mice. Methylenetetrahydrofolate reductase activity was elevated while methionine synthase was impaired in atherogenic diet fed group. Impaired methionine synthase activity would adversely affect the methionine synthesis from homocysteine, resulting in a rise in the homocysteine levels, which are atherogenic. This is reflected by the increased levels of very low density and low density lipoprotein cholesterol values and a higher ratio for total cholesterol to high density lipoprotein cholesterol.
在喂食致动脉粥样硬化饮食的小鼠中，研究了参与同型半胱氨酸合成蛋氨酸的两种关键酶，即亚甲基四氢叶酸还原酶和蛋氨酸合酶。在喂食致动脉粥样硬化饮食的组中，亚甲基四氢叶酸还原酶活性升高，而蛋氨酸合酶受损。蛋氨酸合酶活性受损会对同型半胱氨酸合成蛋氨酸产生不利影响，导致同型半胱氨酸水平升高，而这具有致动脉粥样硬化性。这表现为极低密度脂蛋白和低密度脂蛋白胆固醇值水平升高，以及总胆固醇与高密度脂蛋白胆固醇的比率更高。
