Hackman A S, Wilkins T D
Antimicrob Agents Chemother. 1975 May;7(5):698-703. doi: 10.1128/AAC.7.5.698.
A mixed infection of Bacteroides fragilis and Fusobacterium necrophorum was resistant to treatment with penicillin even though a pure F. necrophorum infection could be successfully treated with penicillin. Since B. fragilis alone did not produce infection, these results indicate that B. fragilis can protect F. necrophorum from penicillin in vivo. The extent of protection afforded by a strain of B. fragilis was related to its level of resistance to penicillin. Only a few cells of B. fragilis were required in the initial bacterial injection. Moreover, protection was demonstrated when B. fragilis cells were injected as late as 24 h after the F. necrophorum cells. Protection of F. necrophorum from penicillin by B. fragilis was also demonstrated in vitro.
脆弱拟杆菌和坏死梭杆菌的混合感染对青霉素治疗具有抗性，尽管单纯的坏死梭杆菌感染可用青霉素成功治疗。由于单独的脆弱拟杆菌不会引发感染，这些结果表明脆弱拟杆菌在体内可保护坏死梭杆菌免受青霉素的影响。脆弱拟杆菌菌株提供的保护程度与其对青霉素的抗性水平有关。在最初的细菌注射中仅需少量脆弱拟杆菌细胞。此外，在坏死梭杆菌细胞注射后24小时再注射脆弱拟杆菌细胞时，也证明了这种保护作用。脆弱拟杆菌对坏死梭杆菌的青霉素保护作用在体外也得到了证实。
