Róka R, Séra T, Valkusz Z, Julesz J, Csernay L, Pávics L
Központi Izotópdiagnosztikai Laboratórium, Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
Orv Hetil. 1999 Jun 6;140(23):1291-5.
Since 1993, outpatient radioiodine therapy has been available in Hungary. The reported study evaluated the efficacy of outpatient radioiodine treatment in subjects with hyperthyroidism. The data on 118 patients with Graves' disease and 36 patients with thyroid autonomy were analysed retrospectively. All patients were treated within the period 1994-1997. The activities of radioiodine were individually calculated. The applied dose in Graves' disease was 150 Gy, and in thyroid autonomy 150 Gy or 300 Gy. The efficacy of the treatment were evaluated 3, 6, and 12 months after radioiodine therapy. In patients with persistent hyperthyroidism repeated therapies were performed. Overall the radioiodine therapy was successful in 85% of the Graves' disease patients. The first 150 Gy treatment was effective in 70% of the patients with Graves' disease and in 43% of the patients with increased radioiodine turnover. In thyroid autonomy, the treatment with 150 Gy was successful in 71%, with 300 Gy in 89% of the patients. The efficacy of radioiodine treatment was similar to the results of one dose application. It was concluded, that radioiodine therapy with 150 Gy absorbed dose in Graves' disease and with 300 Gy absorbed dose in thyroid autonomy proved successful by the method of the authors.
自1993年起，匈牙利开始提供门诊放射性碘治疗。本报告研究评估了门诊放射性碘治疗甲状腺功能亢进症患者的疗效。对118例格雷夫斯病患者和36例甲状腺自主功能亢进患者的数据进行了回顾性分析。所有患者均在1994年至1997年期间接受治疗。放射性碘的活度进行了个体化计算。格雷夫斯病的应用剂量为150 Gy，甲状腺自主功能亢进症为150 Gy或300 Gy。在放射性碘治疗后3个月、6个月和12个月评估治疗效果。对持续甲状腺功能亢进的患者进行重复治疗。总体而言，放射性碘治疗在85%的格雷夫斯病患者中取得成功。首次150 Gy治疗对70%的格雷夫斯病患者和43%放射性碘周转率增加的患者有效。在甲状腺自主功能亢进症中，150 Gy治疗在71%的患者中成功，300 Gy治疗在89%的患者中成功。放射性碘治疗的疗效与单次给药的结果相似。得出的结论是，作者的方法证明，格雷夫斯病采用150 Gy吸收剂量的放射性碘治疗以及甲状腺自主功能亢进症采用300 Gy吸收剂量的放射性碘治疗是成功的。
