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用于替代关节的垫子形式的水凝胶的双相特性研究。

Investigation into the biphasic properties of a hydrogel for use in a cushion form replacement joint.

作者信息

Goldsmith A A, Clift S E

机构信息

School of Mechanical Engineering, University of Bath, United Kingdom.

出版信息

J Biomech Eng. 1998 Jun;120(3):362-9. doi: 10.1115/1.2798003.

DOI:10.1115/1.2798003
PMID:10412404
Abstract

A hydrogel with potential applications in the role of a cushion form replacement joint bearing surface material has been investigated. The material properties are required for further development and design studies and have not previously been quantified. Creep indentation experiments were therefore performed on samples of the hydrogel. The biphasic model developed by Mow and co-workers (Mak et al., 1987; Mow et al., 1989a) was used to curve-fit the experimental data to theoretical solutions in order to extract the three intrinsic biphasic material properties of the hydrogel (aggregate modulus, HA, Poisson's ratio, Vs, and permeability, k). Ranges of material properties were determined: aggregate modulus was calculated to be between 18.4 and 27.5 MPa, Poisson's ratio 0.0-0.307, and permeability 0.012-7.27 x 10(-17) m4/Ns. The hydrogel thus had a higher aggregate modulus than values published for natural normal articular cartilage, the Poisson's ratios were similar to articular cartilage, and finally the hydrogel was found to be less permeable than articular cartilage. The determination of these values will facilitate further numerical analysis of the stress distribution in a cushion form replacement joint.

摘要

一种在替代关节轴承表面材料的衬垫形式中具有潜在应用的水凝胶已被研究。材料特性对于进一步的开发和设计研究是必需的,且此前尚未进行量化。因此,对水凝胶样品进行了蠕变压痕实验。采用Mow及其同事开发的双相模型(Mak等人,1987年;Mow等人,1989a)将实验数据与理论解进行曲线拟合,以提取水凝胶的三种内在双相材料特性(聚集模量,HA,泊松比,Vs,以及渗透率,k)。确定了材料特性的范围:聚集模量经计算在18.4至27.5兆帕之间,泊松比为0.0 - 0.307,渗透率为0.012 - 7.27×10(-17) 平方米4/牛顿秒。因此,该水凝胶的聚集模量高于已发表的天然正常关节软骨的值,泊松比与关节软骨相似,最后发现该水凝胶的渗透率低于关节软骨。这些值的确定将有助于对替代关节衬垫形式中的应力分布进行进一步的数值分析。

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