Athanasiou K A, Rosenwasser M P, Buckwalter J A, Malinin T I, Mow V C
Department of Mechanical Engineering, Columbia University, New York, New York.
J Orthop Res. 1991 May;9(3):330-40. doi: 10.1002/jor.1100090304.
We measured the in situ biomechanical properties of knee joint cartilage from five species (bovine, canine, human, monkey, and rabbit) to examine the biomechanical relevance of animal models of human knee joint injuries and osteoarthritis. In situ biphasic creep indentation experiments were performed to simultaneously determine all three intrinsic material coefficients (aggregate modulus, Poisson's ratio, and permeability) of the cartilage as represented by the linear KLM biphasic model. In addition, we also assessed the effects of load bearing on these intrinsic properties at "high" and "low" weight-bearing regions on the distal femur. Our results indicate that significant differences exist in some of these material properties among species and sites. The aggregate modulus of the anterior patellar groove within each species is the lowest among all sites tested, and the permeability of the patellar groove cartilage is the highest and does not vary among species. Similarly, the Poison's ratio in the patellar groove is the lowest in all species, except in the rabbit. These results lead to the conclusion that patellar groove cartilage can undergo greater and faster compression. Thus, under high compressive loads, the cartilage of the patellar groove surface can more rapidly compress to create a congruent patellofemoral joint articulation. For any given location, no differences were found in the aggregate modulus among all the species, and no correlation was found between aggregate modulus and thickness at the test site. Thus, in the process of selecting a suitable experimental animal model of human articular cartilage, it is essential to consider the significant interspecies differences of the mechanical properties.
我们测量了五种物种（牛、犬、人、猴和兔）膝关节软骨的原位生物力学特性，以研究人类膝关节损伤和骨关节炎动物模型的生物力学相关性。进行了原位双相蠕变压痕实验，以同时确定由线性KLM双相模型表示的软骨的所有三个固有材料系数（聚集模量、泊松比和渗透率）。此外，我们还评估了在股骨远端“高”和“低”负重区域负重对这些固有特性的影响。我们的结果表明，这些材料特性在物种和部位之间存在显著差异。每个物种中髌前沟的聚集模量在所有测试部位中是最低的，髌沟软骨的渗透率是最高的，并且在物种之间没有变化。同样，除了兔子外，所有物种中髌沟的泊松比都是最低的。这些结果得出结论，髌沟软骨可以经历更大和更快的压缩。因此，在高压缩载荷下，髌沟表面的软骨可以更快地压缩以形成一致的髌股关节连接。对于任何给定位置，所有物种之间的聚集模量没有差异，并且在测试部位聚集模量与厚度之间没有相关性。因此，在选择合适的人类关节软骨实验动物模型的过程中，考虑力学性能的显著种间差异至关重要。
