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与儿童结节病相关的膜性肾病。

Membranous nephropathy associated with childhood sarcoidosis.

作者信息

Dimitriades C, Shetty A K, Vehaskari M, Craver R D, Gedalia A

机构信息

Department of Pediatrics, Louisiana State University Medical Center and Children's Hospital, New Orleans 70112, USA.

出版信息

Pediatr Nephrol. 1999 Jun;13(5):444-7. doi: 10.1007/s004670050637.

Abstract

Sarcoidosis is a chronic multisystemic granulomatous disease of unknown etiology. It is relatively rare in children. Renal involvement in sarcoidosis is described less commonly than other organ involvement such as pulmonary, eye, musculoskeletal, and skin. We report a 13-year-old girl with sarcoidosis and nephrotic syndrome. Renal biopsy showed findings of membranous nephropathy. She received intravenous pulse methylprednisolone and oral cyclophosphamide with resolution of the symptoms of fever and edema, and improvement of the proteinuria. Her condition is stable with no progression of her renal disease. To the best of our knowledge, this is the first report of membranous nephropathy associated with childhood sarcoidosis.

摘要

结节病是一种病因不明的慢性多系统肉芽肿性疾病。它在儿童中相对罕见。与肺部、眼睛、肌肉骨骼和皮肤等其他器官受累相比,结节病累及肾脏的情况较少被描述。我们报告一名患有结节病和肾病综合征的13岁女孩。肾活检显示为膜性肾病的表现。她接受了静脉注射甲泼尼龙冲击治疗和口服环磷酰胺,发热和水肿症状消退,蛋白尿改善。她的病情稳定,肾病未进展。据我们所知,这是第一例与儿童结节病相关的膜性肾病报告。

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