Gaudenz R, Hartmann K, Reinhart W H, Kuhn M
Medizinische Klinik, Rätisches Kantons- und Regionalspital, Chur.
Praxis (Bern 1994). 1999 Jun 3;88(23):1047-51.
A 74 year old man developed progressive dyspnea under treatment with the tetracyclic antidepressant maprotiline for three months. A chest x-ray revealed extended pulmonary infiltrates. Marked eosinophilia of the periperal blood was found (up to 2300/microliter). Rapid clinical and radiological improvement was observed solely by withholding the drug. The eosinophil count retourned to normal within a few weeks. The possible pathogenesis is discussed and the literature reviewed.
一名74岁男性在接受四环类抗抑郁药马普替林治疗三个月后出现进行性呼吸困难。胸部X线显示肺部浸润扩大。外周血发现明显嗜酸性粒细胞增多（高达2300/微升）。仅通过停用该药物就观察到临床和影像学迅速改善。嗜酸性粒细胞计数在几周内恢复正常。讨论了可能的发病机制并回顾了相关文献。
