Ostergaard L
Infektionsmedicinsk afdeling Arhus Universitetshospital.
Tidsskr Nor Laegeforen. 1999 Jun 20;119(16):2350-6.
Sexually transmitted Chlamydia trachomatis infections are common and a major cause of pelvic inflammatory disease and its complications (infertility, ectopic pregnancy and chronic abdominal pain). No pathognomonic sign exists and the majority of infected individuals are asymptomatic. During the last eight years numerous evaluations of methods of detecting C trachomatis infections by use of DNA amplification have been published. The clinical sensitivity of the methods seem to be superior to antigen detection methods and cell culture. However, inhibitoric components may reduce the sensitivity of certain DNA tests and sample types. The increased sensitivity of DNA amplification tests allows the use of sample material which contain fewer organisms than the conventional swab sample, e.g. urine and vaginal samples. A strategy using home-obtained and mailed samples increases the efficacy of contact tracing and universal screening. Wider use of this strategy may reduce the risk of complications for the individual and reduce the prevalence of the infection in the society.
性传播沙眼衣原体感染很常见，是盆腔炎及其并发症（不孕、宫外孕和慢性腹痛）的主要原因。不存在特征性体征，大多数感染者无症状。在过去八年中，已经发表了许多关于使用DNA扩增检测沙眼衣原体感染方法的评估。这些方法的临床敏感性似乎优于抗原检测方法和细胞培养。然而，抑制性成分可能会降低某些DNA检测和样本类型的敏感性。DNA扩增检测灵敏度的提高使得可以使用比传统拭子样本含菌量更少的样本材料，例如尿液和阴道样本。使用自行采集并邮寄样本的策略可提高接触者追踪和普遍筛查的效果。更广泛地使用这种策略可能会降低个体发生并发症的风险，并降低社会上该感染的流行率。
