Verma S, Bhanot S, McNeill J H
Division of Cardiology Foothills Hospital, Calgary, AB, Canada.
Eur J Pharmacol. 1999 Jun 4;373(2-3):R1-4. doi: 10.1016/s0014-2999(99)00301-5.
The fructose-induced hypertensive rat is a widely used model to study the inter-relationship between hyperinsulinemia, insulin resistance and high blood pressure. Evidence suggests that hyperinsulinemia and insulin resistance may be pathogenic in the development of high blood pressure in this model. To determine the contribution of the sympathetic nervous system towards fructose-induced hypertension, the present study examined the effects of chemical sympathectomy (adrenal medullectomy, followed by weekly 6-hydroxydopamine injections) on plasma insulin levels and systolic blood pressure in control and fructose-induced hypertensive rats. Sympathectomy abrogated the development of both hyperinsulinemia and hypertension in fructose hypertensive rats without affecting these parameters in control rats. These data uncover, for the first time, the primacy of the sympathetic nervous system as a mediator of both elevated plasma insulin levels and high blood pressure in rats fed a high fructose diet.
果糖诱导的高血压大鼠是一种广泛用于研究高胰岛素血症、胰岛素抵抗和高血压之间相互关系的模型。有证据表明，在该模型中，高胰岛素血症和胰岛素抵抗可能是高血压发病的原因。为了确定交感神经系统在果糖诱导的高血压中的作用，本研究检测了化学性交感神经切除术（肾上腺髓质切除术，随后每周注射6-羟基多巴胺）对正常对照大鼠和果糖诱导的高血压大鼠血浆胰岛素水平和收缩压的影响。交感神经切除术消除了果糖高血压大鼠高胰岛素血症和高血压的发展，而对正常对照大鼠的这些参数没有影响。这些数据首次揭示了交感神经系统在喂食高果糖饮食的大鼠中作为血浆胰岛素水平升高和高血压介导因素的首要地位。
