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[某种物质]丁醇部位对大鼠果糖介导的代谢改变的保护作用。 （注：原文中“of”后面缺少具体物质名称）

Protective Effect of Butanolic Fraction of on Fructose-Mediated Metabolic Alterations in Rats.

作者信息

Bukhari Syed Nasir Abbas, Asif Hira, Asim Mulazim Hussain, Muhammad Irfan Hafiz, Ejaz Hasan, Elsherif Mervat A, Junaid Kashaf

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Al Jouf, Saudi Arabia.

Lahore Pharmacy College, Lahore Medical and Dental College, Lahore 54850, Pakistan.

出版信息

Metabolites. 2022 May 26;12(6):481. doi: 10.3390/metabo12060481.

DOI:10.3390/metabo12060481
PMID:35736413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9227329/
Abstract

The present study was conducted with an intent to evaluate the protective effect of butanolic fraction of on fructose mediated metabolic abnormalities in rats. Rats in all groups except control group were fed on 10% fructose for 6 weeks; however, rats in the treated group also received butanolic fraction for the last 3 weeks, along with the fructose. Moreover, phytoconstituents present in butanolic fraction were analyzed using LC-MS. All doses of butanolic fraction profoundly reduce the fructose-induced blood pressure, sympathetic over-activity, and weight gain. Furthermore, butanolic fraction prominently reduces the glucose intolerance and hyperinsulinemia in fructose-fed rats. On treatment with butanolic fraction, oxidative enzymes and the functionality of the aorta was also restored. Phytochemical analysis revealed the presence of several active constituents including bergenin, scopolin, rutinoside, kaempferol, coumaric acid, apigenin, and gingerol. In conclusion, butanolic fraction of has the potential to prevent and recover the fructose-induced metabolic perturbations.

摘要

本研究旨在评估[植物名称]丁醇部位对果糖介导的大鼠代谢异常的保护作用。除对照组外，所有组大鼠均喂食10%果糖，持续6周；然而，治疗组大鼠在最后3周除了果糖外，还接受丁醇部位给药。此外，使用液相色谱-质谱联用仪（LC-MS）分析了丁醇部位中的植物成分。所有剂量的丁醇部位均能显著降低果糖诱导的血压、交感神经过度活动和体重增加。此外，丁醇部位能显著降低喂食果糖大鼠的葡萄糖不耐受和高胰岛素血症。用丁醇部位治疗后，氧化酶活性和主动脉功能也得以恢复。植物化学分析表明存在几种活性成分，包括岩白菜素、东莨菪苷、芸香苷、山柰酚、香豆酸、芹菜素和姜辣素。总之，[植物名称]丁醇部位有预防和恢复果糖诱导的代谢紊乱的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/fc04d36da4ee/metabolites-12-00481-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/f1ee8c387343/metabolites-12-00481-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/01edde86e7e8/metabolites-12-00481-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/783f286d5042/metabolites-12-00481-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/e0c182cee33a/metabolites-12-00481-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/383da877b229/metabolites-12-00481-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/ce95ed11cef0/metabolites-12-00481-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/764f84afde40/metabolites-12-00481-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/b952d31c26d0/metabolites-12-00481-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/aad3a6efc9a6/metabolites-12-00481-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/fc04d36da4ee/metabolites-12-00481-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/f1ee8c387343/metabolites-12-00481-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/01edde86e7e8/metabolites-12-00481-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/783f286d5042/metabolites-12-00481-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/e0c182cee33a/metabolites-12-00481-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/383da877b229/metabolites-12-00481-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/ce95ed11cef0/metabolites-12-00481-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/764f84afde40/metabolites-12-00481-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/b952d31c26d0/metabolites-12-00481-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/aad3a6efc9a6/metabolites-12-00481-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe13/9227329/fc04d36da4ee/metabolites-12-00481-g010.jpg

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