Quiles J L, Ramirez-Tortosa M C, Huertas J R, Ibañez S, Gomez J A, Battino M, Mataix J
Nutrition and Food Technology Institute, University of Granada, Spain.
Biofactors. 1999;9(2-4):331-6. doi: 10.1002/biof.5520090232.
In this study we have evaluated the supplementation of olive oil with vitamin E on coenzyme Q concentration and lipid peroxidation in rat liver mitochondrial membranes. Four groups of rats were fed on virgin olive, olive plus 200 mg/kg of vitamin E or sunflower oils as lipid dietary source. To provoke an oxidative stress rats were administered intraperitoneally 10 mg/kg/day of adriamycin the last two days of the experiment. Animals fed on olive oil plus vitamin E had significantly higher coenzyme Q and vitamin E levels but a lower mitochondrial hydroperoxide concentration than rats fed on olive oil. Retinol levels were not affected, by either different diets or adriamycin treatment. In conclusion, an increase in coenzyme Q and alpha-tocopherol in these membranes can be a basis for protection against oxidation and improvement in antioxidant capacity.
在本研究中，我们评估了在橄榄油中添加维生素E对大鼠肝线粒体膜中辅酶Q浓度和脂质过氧化的影响。四组大鼠分别以初榨橄榄油、添加200 mg/kg维生素E的橄榄油或葵花籽油作为脂质饮食来源。在实验的最后两天，给大鼠腹腔注射10 mg/kg/天的阿霉素以引发氧化应激。与喂食橄榄油的大鼠相比，喂食添加维生素E橄榄油的动物体内辅酶Q和维生素E水平显著更高，但线粒体过氧化氢浓度更低。不同饮食或阿霉素处理均未影响视黄醇水平。总之，这些膜中辅酶Q和α-生育酚的增加可能是防止氧化和提高抗氧化能力的基础。
