Huertas J R, Martinez-Velasco E, Ibáñez S, López-Frias M, Ochoa J J, Quiles J, Parenti Castelli G, Mataix J, Lenaz G
Department of Physiology, University of Granada, Spain.
Biofactors. 1999;9(2-4):337-43. doi: 10.1002/biof.5520090233.
The mitochondrial theory of aging suggests that this phenomenon is the consequence of random somatic mutations in mitochondrial DNA, induced by long-term exposure to free radical attack. There are two potential dietary means of delaying the effects of free radicals on cellular aging, i.e., enrichment of mitochondrial membranes with monounsaturated fatty acids and supplementation with antioxidants. We have performed a preliminary study on male rats, 6 or 12 month old, fed with diets differing in the nature of the fat (virgin olive oil or sunflower oil) and/or with antioxidant supplementation (coenzyme Q10), analysing hydroperoxide and coenzyme Q9 and Q10 in heart mitochondria. Preliminary results allow us to conclude that the CoQ10 dietetic supplementation as well as the enrichment of the cellular membranes with monounsaturated fatty acids, successfully protect mitochondrial membranes from aged rats against the free radical insult.
衰老的线粒体理论认为，这种现象是长期暴露于自由基攻击下，线粒体DNA发生随机体细胞突变的结果。有两种潜在的饮食方法可以延缓自由基对细胞衰老的影响，即在线粒体膜中富集单不饱和脂肪酸和补充抗氧化剂。我们对6个月或12个月大的雄性大鼠进行了一项初步研究，给它们喂食脂肪性质不同（初榨橄榄油或葵花籽油）和/或补充抗氧化剂（辅酶Q10）的饮食，分析心脏线粒体中的氢过氧化物以及辅酶Q9和Q10。初步结果使我们能够得出结论，辅酶Q10的饮食补充以及用单不饱和脂肪酸富集细胞膜，成功地保护了老年大鼠的线粒体膜免受自由基损伤。
