Smith L J
Nurs Clin North Am. 1975 Sep;10(3):481-90.
The analysis of the middle molecule theory has provided a means for reduced time and large surface area dialysis. Increasing the time-surface area product for the dialysis patient has provided a challenge for the dialysis staff. Rapid ultrafiltration necessitates careful and constant monitoring of these patients to prevent complications such as hypotension and cramping. The use of multiple dialyzers to accomplish large surface area dialysis also increases the cost. However, reuse has become a practical and safe way of decreasing the cost without jeopardizing the efficacy of dialysis. Developing a dialysis prescription to meet the particular needs of each patient, based on middle molecule clearance and residual renal function, appears to be an important factor in the future of large surface area dialysis and its adequacy.
中分子理论的分析为缩短透析时间和增加透析表面积提供了一种方法。增加透析患者的时间-表面积乘积给透析工作人员带来了挑战。快速超滤需要对这些患者进行仔细且持续的监测，以预防诸如低血压和痉挛等并发症。使用多个透析器来实现大表面积透析也会增加成本。然而，复用已成为一种在不损害透析疗效的前提下降低成本的实用且安全的方法。根据中分子清除率和残余肾功能制定满足每位患者特殊需求的透析处方，似乎是未来大表面积透析及其充分性的一个重要因素。
