Miyamoto H, Kurita K, Ishimaru J, Goss A N
Department of Dentistry, The University of Adelaid, South Australia, Australia.
J Oral Maxillofac Surg. 1999 Jul;57(7):812-7. doi: 10.1016/s0278-2391(99)90822-4.
The purpose of this study was to develop an animal model for temporomandibular joint (TMJ) ankylosis.
Five sheep had removal of the temporal and condylar articular surface plus discectomy in the right TMJ; the left side was used as a control. One sheep was killed just after operation and four at 3 months. The joints were examined histologically, and a scoring system was developed to evaluate the extent of the ankylosis. The range of jaw movement was compared between preoperatively and 3 months.
Two sheep lost 4% of their body weight by 3 months. The range of jaw movement, particularly to the left, decreased at 3 months (P < .001). The joint spaces were filled with fibrous tissue and cartilage-like tissue. Development of new bone from the damaged temporal and condylar surfaces was seen, but full bony fusion did not occur. The average histologic score of a zone was 4.9 on the degree-of-ankylosis scale and 1.7 on the degree-of-calcification scale. There were statistically significant differences between the operated and control TMJs for both changes (P < .0001).
Fibrous ankylosis occurs rapidly after removal of the TMJ articular surfaces and the disc. This model can be further developed to isolate relative factors in the development of ankylosis and in evaluation of different treatment methods.
本研究的目的是建立一种颞下颌关节（TMJ）强直的动物模型。
五只绵羊右侧颞下颌关节进行颞骨和髁突关节面切除加椎间盘切除术；左侧作为对照。一只绵羊术后即刻处死，四只在3个月时处死。对关节进行组织学检查，并制定评分系统以评估强直程度。比较术前和3个月时的下颌运动范围。
两只绵羊到3个月时体重减轻了4%。3个月时下颌运动范围，尤其是向左的运动范围减小（P <.001）。关节间隙充满纤维组织和软骨样组织。可见从受损的颞骨和髁突表面有新骨形成，但未发生完全骨融合。在强直程度量表上，一个区域的平均组织学评分为4.9，在钙化程度量表上为1.7。两种变化在手术侧和对照侧颞下颌关节之间均有统计学显著差异（P <.0001）。
颞下颌关节关节面和椎间盘切除后迅速发生纤维性强直。该模型可进一步完善，以分离出强直发生过程中的相关因素，并用于评估不同的治疗方法。
