Mancuso G, Berdondini R M, Cavrini G
Department of Dermatology of Municipal Hospital of Lugo, Ravenna, Italy.
Contact Dermatitis. 1999 Jul;41(1):35-9. doi: 10.1111/j.1600-0536.1999.tb06205.x.
The purpose of this study was to determine the duration of patch test reactions and the frequency of long-lasting allergic patch test reactions (LLAPTR), and to identify the possible factors related to the development of the LLAPTR. For this purpose, a group of 263 patients positive to 1 or more allergens in the GIRDCA standard series was recruited. Readings were made for each patient 2 and 3 days after patch test application and continued every 2nd and 3rd day until the disappearance of all palpable erythema. The % of LLAPTR out of the total of reactions was high: 17.9%). Kathon CG was the hapten that caused LLAPTR most frequently, with 16 cases, a frequency of 76.1%), and a mean duration of the patch test reactions of 25.4 days. Risk factors investigated were age, sex, atopy, intensity of the patch test reaction and sensitivity to some allergens with the greatest number of positive patch tests. The relative importance of each risk factor was calculated by multivariate stepwise logistic regression analysis. It was found that a Kathon CG sensitivity was the most important risk factor for LLAPTR. 2nd was atopy, followed by strong patch test reaction. Rejected risk factors were sex, age and sensitivity to nickel sulfate, potassium dichromate, Disperse Blue 124, fragrance mix and p-phenylenediamine.
本研究的目的是确定斑贴试验反应的持续时间以及长期过敏性斑贴试验反应（LLAPTR）的频率，并确定与LLAPTR发生相关的可能因素。为此，招募了一组263名对GIRDCA标准系列中1种或更多变应原呈阳性反应的患者。在斑贴试验应用后第2天和第3天对每位患者进行读数，并每隔2天和3天继续读数，直至所有可触及的红斑消失。LLAPTR在总反应中的比例很高（17.9%）。卡松CG是最常引起LLAPTR的半抗原，有16例，频率为76.1%，斑贴试验反应的平均持续时间为25.4天。所研究的风险因素包括年龄、性别、特应性、斑贴试验反应强度以及对斑贴试验阳性数量最多的某些变应原的敏感性。通过多变量逐步逻辑回归分析计算每个风险因素的相对重要性。结果发现，对卡松CG敏感是LLAPTR最重要的风险因素。其次是特应性，然后是强烈的斑贴试验反应。被排除的风险因素是性别、年龄以及对硫酸镍、重铬酸钾、分散蓝124、香料混合物和对苯二胺的敏感性。
