Mancuso Giuseppe
Giuseppe Mancuso, MD, Via Pescantini 33, 48022 Lugo Ravenna, Italy;
Acta Dermatovenerol Croat. 2017 Oct;25(3):238-244.
Long-lasting allergic patch test reactions (LLAPTR) are those in which the clinical features of palpable erythema are still present at the site of a positive allergic patch test reaction 14 or more days after application of the allergen. LLAPTR have been described for a wide range of contact allergens, many of these included in the baseline patch test series. LLAPTR are far from uncommon; they occur in consecutive patients with positive patch tests to baseline allergens with frequency up to 17.9% of the total reactions. Patch test reactions persisting for a very long time (up to several months after the test) have been described, the most frequent ones being those induced by gold salts. The pathomechanisms of LLAPTR have not been clarified, but may hypothetically involve a constant antigen stimulation and/or a defect in cell-mediated immunity down-regulation. Host-related factors significantly associated with LLAPTR are, according to some studies, a strong initial patch test response, older age, and atopy. No significant sex differences have been observed in the frequency of LLAPTR.
长期过敏性斑贴试验反应（LLAPTR）是指在应用变应原14天或更长时间后，阳性过敏性斑贴试验反应部位仍存在可触及红斑临床特征的反应。LLAPTR已被描述于多种接触性变应原，其中许多包含在基线斑贴试验系列中。LLAPTR并不罕见；在对基线变应原斑贴试验呈阳性的连续患者中，其发生率高达总反应的17.9%。已描述了斑贴试验反应持续很长时间（试验后长达数月）的情况，最常见于金盐诱导的反应。LLAPTR的发病机制尚未阐明，但据推测可能涉及持续的抗原刺激和/或细胞介导免疫下调缺陷。根据一些研究，与LLAPTR显著相关的宿主相关因素是强烈的初始斑贴试验反应、年龄较大和特应性。在LLAPTR的发生率方面未观察到显著的性别差异。
