长期治疗的青光眼患者眼周噻吗洛尔和倍他洛尔的蓄积情况。
Periocular accumulation of timolol and betaxolol in glaucoma patients under long-term therapy.
作者信息
Sponsel W E, Terry S, Khuu H D, Lam K W, Frenzel H
机构信息
Department of Ophthalmology, University of Texas Health Science Center, San Antonio 78284-6230, USA.
出版信息
Surv Ophthalmol. 1999 Jun;43 Suppl 1:S210-3. doi: 10.1016/s0039-6257(99)00014-4.
PURPOSE
To determine if betaxolol or timolol is present in measurable concentration in the Tenon capsule in patients under long-term topical therapy.
METHODS
Small (1-cc) specimens of Tenon capsule were removed at the time of filtering surgery from 15 glaucoma patients under long-term preoperative topical therapy, nine of whom had been treated with timolol and six of whom had been receiving betaxolol. Methanol extracts of these tissue samples were analyzed quantitatively for the presence of either beta-adrenergic antagonist by high-performance liquid chromatography.
RESULTS
Drug was detected in every specimen. A mean total of 2.6 (range, 0.1-30.0) microg of betaxolol was detected per 1-cc specimen.
CONCLUSION
Timolol and betaxolol penetrate the conjunctiva and accumulate in the Tenon capsule. In patients under long-term therapy, the periocular tissue can accumulate a greater quantity of beta-antagonist than is present in a daily dosage of applied eyedrops, manyfold higher than the maximal intraocular concentration.
目的
确定长期局部治疗的患者中，替莫洛尔或倍他洛尔在眼球筋膜囊内是否存在可测量浓度。
方法
在滤过性手术时，从15例长期接受术前局部治疗的青光眼患者中取出小的（1立方厘米）眼球筋膜囊标本，其中9例曾用替莫洛尔治疗，6例接受倍他洛尔治疗。通过高效液相色谱法定量分析这些组织样品的甲醇提取物中β-肾上腺素能拮抗剂的存在情况。
结果
在每个标本中均检测到药物。每1立方厘米标本平均共检测到2.6（范围0.1 - 30.0）微克倍他洛尔。
结论
替莫洛尔和倍他洛尔穿透结膜并积聚在眼球筋膜囊内。在长期治疗的患者中，眼周组织可积聚比每日应用眼药水剂量中所含更多的β-拮抗剂，比最大眼内浓度高许多倍。
Zotero 插件