Schliephake H, Neukam F W, Schmelzeisen R, Wichmann M
Department of Oral and Maxillofacial Surgery, Medizinische Hochschule Hannover, Germany.
Int J Oral Maxillofac Surg. 1999 Aug;28(4):260-5.
The aim of the present study was to analyse the long-term survival rate of endosteal implants used for restoration of oral function in patients having undergone oncologic surgery. Eighty-three consecutive patients, who had received a total of 409 endosteal implants ad modum Brånemark, subsequent to resections of soft tissue and bone during ablation of oral malignancies, were enrolled into the study. A life-table analysis was used to determine the survival rate of the implants placed during a period of 13 years. Log rank tests and Cox regression analysis were employed to identify relevant effects of surgical parameters on implant survival. A total of 38 implant failures were encountered. Most of the losses (n = 19) occurred during the first year of functional loading. Subsequent failures were evenly distributed across the remaining follow-up period. The cumulative overall survival rate of implants was 56.5%. Previous radiation therapy, insertion into grafted bone or original jaw bone and the technique of grafting did not significantly affect the survival rates. In the Cox regression analysis, the timing of implant placement in the group of patients with bone grafts (primary vs. secondary placement) was significantly related to the survival rate (P = 0.0197), with a lower survival rate of 36.2% for primary insertion of implants and 67.1% for secondary placement.
本研究的目的是分析用于接受肿瘤手术患者口腔功能修复的骨内种植体的长期存活率。连续83例患者，在口腔恶性肿瘤切除术中进行软组织和骨切除后，总共接受了409枚Brånemark式骨内种植体，被纳入本研究。采用寿命表分析法确定13年期间植入种植体的存活率。采用对数秩检验和Cox回归分析来确定手术参数对种植体存活的相关影响。共发生38例种植体失败。大多数失败（n = 19）发生在功能加载的第一年。随后的失败在其余随访期间均匀分布。种植体的累积总存活率为56.5%。先前的放射治疗、植入移植骨或原颌骨以及移植技术对存活率没有显著影响。在Cox回归分析中，骨移植患者组中种植体植入的时间（一期植入与二期植入）与存活率显著相关（P = 0.0197），一期植入种植体的存活率较低，为36.2%，二期植入为67.1%。
