本月病例：1999年3月——一名26岁的HIV阳性男性，患有硬脑膜肿物。
Case of the month: March 1999--A 26 year old HIV positive male with dura based masses.
作者信息
Karpinski N C, Yaghmai R, Barba D, Hansen L A
机构信息
Department of Pathology (Neuropathology), UCSD Medical Center, San Diego, CA, USA.
出版信息
Brain Pathol. 1999 Jul;9(3):609-10. doi: 10.1111/j.1750-3639.1999.tb00609.x.
A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neoplasms with long slender nuclei, consistent with leiomyomas. Both tumors were positive for Epstein Barr virus by in situ hybridization. This case report serves to emphasize the importance of considering soft tissue tumors such as leiomyoma in the differential diagnosis of mass lesions that occur in the central nervous system in AIDS and discusses the role of EBV in tumorigenesis.
一名26岁的艾滋病男性患者，主要症状为头痛和颈部疼痛。磁共振成像（MRI）显示两个位于轴外硬膜的强化肿块，一个在左侧蝶骨翼区域，另一个在C2 - 3水平。在这两个病例中，显微镜切片显示肌动蛋白阳性的梭形细胞瘤，核长而细，符合平滑肌瘤。通过原位杂交检测，这两个肿瘤的爱泼斯坦 - 巴尔病毒（EBV）均呈阳性。本病例报告旨在强调在艾滋病患者中枢神经系统肿块病变的鉴别诊断中考虑平滑肌瘤等软组织肿瘤的重要性，并讨论EBV在肿瘤发生中的作用。
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