Kanitakis J, Bourchany D, Faure M, Claudy A
Laboratory of Dermatopathology, Department of Dermatology, Edouard-Herriot Hospital, 69437 Lyon Cedex 03, France.
Eur J Dermatol. 1999 Jul-Aug;9(5):363-5.
Keratin 15 (K15) was recently shown to be a specific marker of stem cells of the hair-follicle bulge. We studied the reactivity of an antibody to the CD8 antigen (C8/144B), recognizing K15, on 66 cutaneous tumors with known or alleged pilar differentiation, in order to assess its usefulness in the diagnosis of this group of tumors. 2/2 basal cell nevi, 5/8 trichoepitheliomas and 1/3 trichofolliculomas showed substantial reactivity. Much weaker reactivity was observed in cases of trichilemmal tumors (trichilemmomas and trichilemmal cysts); by contrast, all cases of pilomatricomas, basal cell carcinomas and epidermoid cysts were completely unreactive. These results are in keeping with the admitted differentiation of the tumors studied, and suggest further that basal cell carcinomas do not differentiate towards hair bulge cells. From a practical point of view, immunostaining for K15 seems to be an additional useful adjunct for the differential diagnosis between basal cell carcinoma and trichoepithelioma.
角蛋白15（K15）最近被证明是毛囊隆突部干细胞的一种特异性标志物。我们研究了一种识别K15的抗CD8抗原抗体（C8/144B）对66例已知或疑似毛囊分化的皮肤肿瘤的反应性，以评估其在这类肿瘤诊断中的作用。2例基底细胞痣、5例毛发上皮瘤和1例毛囊瘤显示出明显的反应性。在毛鞘瘤（毛鞘瘤和毛鞘囊肿）病例中观察到的反应性要弱得多；相比之下，所有的毛母质瘤、基底细胞癌和表皮样囊肿病例均完全无反应。这些结果与所研究肿瘤公认的分化情况相符，进一步表明基底细胞癌不会向毛囊隆突细胞分化。从实际角度来看，K15免疫染色似乎是基底细胞癌和毛发上皮瘤鉴别诊断的一种额外有用的辅助手段。
