左旋布比卡因与布比卡因抗菌活性的比较：一项针对与硬膜外感染相关细菌的体外研究。

A comparison of the antibacterial activity of levobupivacaine vs. bupivacaine: an in vitro study with bacteria implicated in epidural infection.

作者信息

Hodson M, Gajraj R, Scott N B

机构信息

Department of Anaesthesia, Health Care International (Scotland) Ltd, Beardmore Street, Clydebank, Glasgow G81 4DY, UK.

出版信息

Anaesthesia. 1999 Jul;54(7):699-702. doi: 10.1046/j.1365-2044.1999.00742.x.

DOI:10.1046/j.1365-2044.1999.00742.x

PMID:10417467

Abstract

The purpose of the study was to compare the antibacterial activity of bupivacaine with levobupivacaine against a range of bacteria implicated in epidural infection to determine whether any differences existed between the two drugs. Concentrations of 0.125%, 0.25% and 0.5% bupivacaine and levobupivacaine were inoculated with suspensions of either Staphylococcus epidermidis, Staphylococcus aureus or Enterococcus faecalis. After incubation, the mixtures were plated onto blood agar and colony counts were recorded after a further period of incubation. The minimum bactericidal concentration of local anaesthetic against the three bacteria studied was found to be 0.25% for bupivacaine and 0.5% for levobupivacaine showing racemic bupivacaine to have a more potent antibacterial action than levobupivacaine. This finding suggests that the dextrobupivacaine isomer of racemic bupivacaine has a more potent antibacterial action than the levobupivacaine isomer.

摘要

本研究的目的是比较布比卡因和左旋布比卡因对一系列与硬膜外感染相关细菌的抗菌活性，以确定这两种药物之间是否存在差异。将浓度为0.125%、0.25%和0.5%的布比卡因和左旋布比卡因分别与表皮葡萄球菌、金黄色葡萄球菌或粪肠球菌的悬液接种。孵育后，将混合物接种到血琼脂平板上，再经过一段时间孵育后记录菌落计数。结果发现，布比卡因对所研究的三种细菌的最低杀菌浓度为0.25%，左旋布比卡因为0.5%，表明消旋布比卡因比左旋布比卡因具有更强的抗菌作用。这一发现表明，消旋布比卡因的右旋布比卡因异构体比左旋布比卡因异构体具有更强的抗菌作用。