Christensen K, Juul L
Department of Animal Science and Animal Health, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Acta Vet Scand. 1999;40(1):85-8. doi: 10.1186/BF03547044.
A case of the rare genetic trisomy 22 in a live calf is described. The calf had low blood thyroxine level and low growth rate. It had several defects including brachygnathia superior, strabismus convergence, aortal cusp insufficiency and hypertrophy of clitoris. Chromosome analysis was performed on cultured blood lymphocytes and fibroblast cells. In all counted metaphases 61 chromosomes were present. The extra chromosome was identified as a chromosome 22 by R-banding. The defects of the calf have similarities with cases of partial trisomy 3p25-pter in human. This section of the human chromosome 3 corresponds to sections of cattle chromosome 22.
本文描述了一例存活小牛中罕见的22号染色体三体的病例。这头小牛血液甲状腺素水平低且生长速度缓慢。它有几个缺陷，包括上颌后缩、内斜视、主动脉瓣尖闭锁不全和阴蒂肥大。对培养的血液淋巴细胞和成纤维细胞进行了染色体分析。在所有计数的中期相中，均有61条染色体。通过R带分析，额外的染色体被鉴定为22号染色体。这头小牛的缺陷与人类3p25 - pter部分三体的病例有相似之处。人类3号染色体的这一部分与牛22号染色体的部分相对应。
